Red Strain Oryza Sativa-Unpolished Thai Rice Prevents Oxidative Stress and ACF in Rats

The bioequilibrium of antioxidant and prooxidant has a crucial role in cellular function with free radical defense (Valko et al., 2006). Oxidative stress is defined by the excess of free radicals and antioxidant depletion. It was implicated on biomolecules such as protein, lipid, and nucleic acid (Sies, 1997; Finkel & Holbrook, 2000). Cellular oxidative stress eventually caused tissue injury and progressed to chronic diseases including cancer (Halliwell, 1987; Valko et al., 2006). Colorectal cancer is described as the malignant neoplasm which arising from an inner lining of colonic epithelium (Rajamanickam & Agarwal, 2008). The early stage of colorectal cancer is generally related to the aberrant crypt foci (ACF), the clusters of colonic epithelial cells with an enlarged and thicker layer of mucosal epithelium than the surrounding normal crypts (Cappell, 2007). The consumption of diet rich in high fat and low phytochemicals is associated with the risk of colorectal cancer (Cappell, 2007; Kim & Milner, 2007). Phytophenolic substances were claimed to prevent